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| Series Regulars | |||
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| Kevin Michael Richardson | Kevin Michael Richardson as Cleveland Brown Jr. | Reagan Gomez-Preston | Reagan Gomez-Preston as Roberta Tubbs |
| Mike Henry | Mike Henry as Cleveland Brown | Sanaa Lathan | Sanaa Lathan as Donna Tubbs |
| Jason Sudeikis | Jason Sudeikis as Holt Richter | Seth MacFarlane | Seth MacFarlane Creator |
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| Recurring & Guests | |||
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| Glenn Howerton | Glenn Howerton as Ernie Krinklesac | Jamie Kennedy | Jamie Kennedy as Federline Jones |
| Will Forte | Will Forte as Principal Wally Farquhare | Nia Long | Nia Long as Roberta Tubbs |
| Alex Borstein | Alex Borstein as Mrs. Lowenstein | | |