| cast |
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| Series Regulars | |||
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| Jonny Lee Miller | Jonny Lee Miller as Eli Stone | Victor Garber | Victor Garber as Jordan Wethersby |
| Natasha Henstridge | Natasha Henstridge as Taylor Wethersby | Sam Jaeger | Sam Jaeger as Matt Dowd |
| James Saito | James Saito as Dr. Frank Chen | Loretta Devine | Loretta Devine as Patti Dellacroix |
| Matt Letscher | Matt Letscher as Nathan Stone | Julie Gonzalo | Julie Gonzalo as Maggie Dekker |
| Jason George | Jason George as Keith Bennett | | |
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| Recurring & Guests | |||
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| Tom Cavanagh | Tom Cavanagh as Jeremy Stone | Laura Benanti | Laura Benanti as Beth Keller |
| Kerr Smith | Kerr Smith as Paul Rollins | Katey Sagal | Katey Sagal as Marci Klein |