| cast |
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| Series Regulars | |||
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| Patrick Wilson | Patrick Wilson as Dr. Michael Holt | Jennifer Ehle | Jennifer Ehle as Anna Paul |
| Margo Martindale | Margo Martindale as Rita Perkins-Hall | Pablo Schreiber | Pablo Schreiber as Anton Little Creek |
| Rachelle Lefevre | Rachelle Lefevre as Dr. Kate Sykora | | |
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| Recurring & Guests | |||
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| Afton Williamson | Afton Williamson as Autumn | Julie Benz | Julie Benz as Christina Holt |
| Liam Aiken | Liam Aiken as Milo | Armando Riesco | Armando Riesco as Tavo |
| Marin Ireland | Marin Ireland as Elena | Rhys Coiro | Rhys Coiro as Dr. Zeke Barnes |