| cast |
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| Series Regulars | |||
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| Hugh Laurie | Hugh Laurie as Dr. Gregory House | Jennifer Morrison | Jennifer Morrison as Dr. Allison Cameron |
| Jesse Spencer | Jesse Spencer as Dr. Robert Chase | Kal Penn | Kal Penn as Dr. Lawrence Kutner |
| Lisa Edelstein | Lisa Edelstein as Dr. Lisa Cuddy | Olivia Wilde | Olivia Wilde as Dr. Remy "Thirteen" Hadley |
| Omar Epps | Omar Epps as Dr. Eric Foreman | Peter Jacobson | Peter Jacobson as Dr. Chris Taub |
| Robert Sean Leonard | Robert Sean Leonard as Dr. James Wilson | | |
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| Recurring & Guests | |||
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| Amber Tamblyn | Amber Tamblyn as Martha M. Masters | Anne Dudek | Anne Dudek as Dr. Amber Volakis |
| Chi McBride | Chi McBride as Edward Vogler | Currie Graham | Currie Graham as Mark Warner |
| Cynthia Watros | Cynthia Watros as Sam Carr | David Morse | David Morse as Michael Tritter |
| Edi Gathegi | Edi Gathegi as Dr. Jeffrey "Big Love" Cole | Odette Yustman | Odette Yustman as Dr. Jessica Adams |
| Sela Ward | Sela Ward as Stacy Warner | | |