| cast |
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| Series Regulars | |||
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| Michael Sheen | Michael Sheen as Dr. William Masters | Lizzy Caplan | Lizzy Caplan as Virginia Johnson |
| Caitlin Fitzgerald | Caitlin Fitzgerald as Libby Masters | Nicholas D'Agosto | Nicholas D'Agosto as Ethan Haas |
| Teddy Sears | Teddy Sears as Dr. Austin Langham | | |
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| Recurring & Guests | |||
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| Margo Martindale | Margo Martindale as Miss Horchow | Beau Bridges | Beau Bridges as Barton Scully |