Film & TV List | Role | Media |
 |
| Hope Springs (2012) | Kay | Movie |
|
| Web Therapy (2012) | Camilla Bowner | TV Show |
|
| The Iron Lady (2011) | Margaret Thatcher | Movie |
|
| Web Therapy (2010) | Camilla Bowner | TV Show |
|
| It's Complicated (2009) | Jane Adler | Movie |
|
| Fantastic Mr. Fox (2009) | Mrs. Fox (voice) | Movie |
|
| Julie & Julia (2009) | Julia Child | Movie |
|
| Doubt (2008) | Sister Aloysius Beauvier | Movie |
|
| Mamma Mia! (2008) | Donna | Movie |
|
| Lions for Lambs (2007) | Janine Roth | Movie |
|
| Rendition (2007) | Corrine Whitman | Movie |
|
| Evening (2007) | Lila Ross | Movie |
|
| Dark Matter (2007) | Joanna Silver | Movie |
|
| The Ant Bully (2006) | Queen (voice) | Movie |
|
| The Devil Wears Prada (2006) | Miranda Priestly | Movie |
|
| A Prairie Home Companion (2006) | Yolanda Johnson | Movie |
|
| Prime (2005) | Lisa Metzger | Movie |
|
| Lemony Snicket's A Series of Unfortunate Events (2004) | Aunt Josephine | Movie |
|
| The Manchurian Candidate (2004) | Eleanor Shaw | Movie |
|
| Angels in America (2003) | Hannah Pitt | TV Movie |
|
| Freedom: A History of Us (2003) | Margaret Chase Smith | TV Show |
|
| The Hours (2002) | Clarissa Vaughan | Movie |
|
| Adaptation. (2002) | Susan Orlean | Movie |
|
| A.I. Artificial Intelligence (2001) | Blue Mecha (voice) | Movie |
|
| King of the Hill (1999) | Aunt Esme Dauterive | TV Show |
|
| Music of the Heart (1999) | Roberta Guaspari | Movie |
|
| Ginevra's Story: Solving the Mysteries of Leonardo da Vinci's First Known Portrait (1999) | Narrator | Movie |
|
| One True Thing (1998) | Kate Gulden | Movie |
|
| Dancing at Lughnasa (1998) | Kate 'Kit' Mundy | Movie |
|
| ...First Do No Harm (1997) | Lori Reimuller | TV Movie |
|
| Marvin's Room (1996) | Lee | Movie |
|
| Before and After (1996) | Dr. Carolyn Ryan | Movie |
|
| The Bridges of Madison County (1995) | Francesca Johnson | Movie |
|
| The Simpsons (1994) | Jessica Lovejoy | TV Show |
|
| The Making of 'The River Wild' (1994) | Gail Hartman | TV Movie |
|
| The River Wild (1994) | Gail Hartman | Movie |
|
| The House of the Spirits (1993) | Clara del Valle Trueba | Movie |
|
| Death Becomes Her (1992) | Madeline Ashton | Movie |
|
| Defending Your Life (1991) | Julia | Movie |
|
| Postcards from the Edge (1990) | Suzanne Vale | Movie |
|
| She-Devil (1989) | Mary Fisher | Movie |
|
| A Cry in the Dark (1988) | Lindy Chamberlain | Movie |
|
| The Tailor of Gloucester (1988) | Narrator | Direct to Video |
|
| Ironweed (1987) | Helen Archer | Movie |
|
| Heartburn (1986) | Rachel Samstat | Movie |
|
| Out of Africa (1985) | Karen | Movie |
|
| Plenty (1985) | Susan Traherne | Movie |
|
| Falling in Love (1984) | Molly Gilmore | Movie |
|
| Silkwood (1983) | Karen Silkwood | Movie |
|
| Sophie's Choice (1982) | Sophie | Movie |
|
| Still of the Night (1982) | Brooke Reynolds | Movie |
|
| Alice at the Palace (1982) | Alice | TV Movie |
|
| The French Lieutenant's Woman (1981) | Sarah | Movie |
|
| Kiss Me, Petruchio (1981) | Katherine | TV Movie |
|
| Kramer vs. Kramer (1979) | Joanna Kramer | Movie |
|
| The Seduction of Joe Tynan (1979) | Karen Traynor | Movie |
|
| Great Performances (1977–1979) | Edith Varney | TV Show |
|
| Manhattan (1979) | Jill | Movie |
|
| The Deer Hunter (1978) | Linda | Movie |
|
| Holocaust (1978) | Inga Helms Weiss | TV Movie |
|
| Julia (1977) | Anne Marie | Movie |
|
| The Deadliest Season (1977) | Sharon Miller | TV Movie |
|
| Everybody Rides the Carousel (1975) | Stage 6 (voice) | Movie |
|