Each night the show's crew and live band crash the bedroom of an unsuspecting celebrity who is forced to host a talk show on the spot without any preparation and on very little sleep. CollegeHumor's Brian Murphy serves as the celebrity's co-host and guide throughout the evening.
"Middle of the Night Show" is produced by Big Breakfast, the production company behind CollegeHumor Originals. Executive producers include Sam Reich, Spencer Griffin and Jon Cohen of Big Breakfast, and Paul Ricci and Dane Reiley of MTV. Brian Murphy will also serve as a producer.