Film & TV List | Role | Media |
 |
| The Five-Year Engagement (2012) | Onion Chef | Movie |
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| Casa de mi Padre (2012) | Sheila | Movie |
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| Up All Night (2011–2012) | Nancy | TV Show |
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| Partners (2012) | Cassandra | TV Show |
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| The Middle. (2011) | Janet | TV Show |
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| Bad Teacher (2011) | Melody (Garrett's Mom) | Movie |
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| Neighbors from Hell (2010) | Tina Hellman | TV Show |
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| Glee (2010) | Brenda Castle | TV Show |
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| Saturday Night Live (1995–2010) | Various
/
Mary Katherine Gallagher
/
Anna Nicole Smith
/ … | TV Show |
|
| Web Therapy (2010) | Kirsten Noble | TV Show |
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| The New Adventures of Old Christine (2009) | Jeannie | TV Show |
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| What Goes Up (2009) | Penelope Little | Movie |
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| Kath & Kim (2008–2009) | Kath Day | TV Show |
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| Igor (2008) | Eva (voice) | Movie |
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| Snow Buddies (2008) | Molly (voice) | Direct to Video |
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| Pushing Daisies (2007) | Dilly Balsam | TV Show |
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| More of Me (2007) | Alice | TV Movie |
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| American Dad! (2005–2007) | Kristy | TV Show |
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| Evan Almighty (2007) | Eve Adams | Movie |
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| 30 Rock (2007) | Katherine Catherine | TV Show |
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| Year of the Dog (2007) | Peggy | Movie |
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| The Mastersons of Manhattan (2007) | Amanda Masterson | TV Movie |
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| Air Buddies (2006) | Molly (voice) | Direct to Video |
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| Gray Matters (2006) | Carrie | Movie |
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| The Amazing Screw-On Head (2006) | Patience the Vampire (voice) | TV Movie |
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| My Gym Partner's a Monkey (2006) | Pretties | TV Show |
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| Talladega Nights: The Ballad of Ricky Bobby (2006) | Mrs. Dennit | Movie |
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| LiTTLEMAN (2006) | Soccer Mom | Movie |
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| Marie Antoinette (2006) | Aunt Victoire | Movie |
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| Cracking Up (2004–2006) | Lesley Shackleton | TV Show |
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| Scary Movie 4 (2006) | Marilyn | Movie |
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| Shut Up and Sing (2006) | Trish | Movie |
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| Here Comes Peter Cottontail: The Movie (2005) | Jackie Frost (voice) | Direct to Video |
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| The Twelve Days of Christmas Eve (2004) | Angie | TV Movie |
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| Scrubs (2004) | Denise Lemmon | TV Show |
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| Will & Grace (1999–2004) | Val Bassett | TV Show |
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| Good Boy! (2003) | Mrs. Baker | Movie |
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| My Boss's Daughter (2003) | Audrey Bennett | Movie |
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| Ed (2003) | Linda Berringer | TV Show |
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| The Music Man (2003) | Mrs. Eulalie Mackechnie Shinn | TV Movie |
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| American Splendor (2003) | Stage Actor Joyce | Movie |
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| The Santa Clause 2 (2002) | Tracy | Movie |
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| Sex and the City (2002) | Lily Martin | TV Show |
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| Serendipity (2001) | Eve | Movie |
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| Osmosis Jones (2001) | Mrs. Boyd | Movie |
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| Saturday Night Live Primetime Extra 1 (2001) | Elizabeth Taylor | TV Movie |
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| Wet Hot American Summer (2001) | Gail von Kleinenstein | Movie |
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| How the Grinch Stole Christmas (2000) | Betty Lou Who | Movie |
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| My 5 Wives (2000) | Barbara Van Dyke | Movie |
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| SNL Fanatic (2000) | Anna Nicole Smith | TV Movie |
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| Superstar (1999) | Mary Katherine Gallagher | Movie |
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| My Neighbors the Yamadas (1999) | Matsuko Yamada (voice: English version) | Movie |
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| Never Been Kissed (1999) | Anita | Movie |
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| Analyze This (1999) | Caroline | Movie |
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| The Thin Pink Line (1998) | Aanl | Movie |
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| A Night at the Roxbury (1998) | Emily Sanderson | Movie |
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| Happiness (1998) | Nancy | Movie |
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| Seinfeld (1997) | Sam | TV Show |
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| The Single Guy (1997) | Melody Pugh | TV Show |
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| Dinner and Driving (1997) | Arguing Woman in Cafe | Movie |
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| Lawnmower Man 2: Beyond Cyberspace (1996) | Homeless Lady | Movie |
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| Return to Two Moon Junction (1995) | Traci | Movie |
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| Sister, Sister (1994) | Cashier | TV Show |
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| Ellen (1994) | Woman | TV Show |
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| The John Larroquette Show (1994) | n/a | TV Show |
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| In Living Color (1992–1993) | Officer Trainee
/
Various | TV Show |
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| General Hospital (1993) | Surrogate Mother #2 | TV Show |
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| Twin Peaks (1991) | Judy Swain | TV Show |
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| The Phantom of the Opera (1989) | Meg (New York) | Movie |
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Film & TV List | Role | Media |
|
| The Late Late Show with Craig Ferguson (2007–2011) | Herself | TV Show |
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| The Talk (2011) | Herself - Co Host
/
Herself - Guest
/
Herself - Co-Host
/ … | TV Show |
|
| The Oprah Winfrey Show (2011) | Herself | TV Show |
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| Watch What Happens: Live (2010) | Guest | TV Show |
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| Late Night with Jimmy Fallon (2010) | Herself | TV Show |
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| Late Night with Conan O'Brien (1999–2008) | Herself | TV Show |
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| The Tonight Show with Jay Leno (2001–2008) | Herself | TV Show |
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| Entertainment Tonight (2008) | Herself | TV Show |
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| Kathy Griffin: My Life on the D-List (2008) | Herself | TV Show |
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| The View (2007) | Herself
/
Herself - Co-Host | TV Show |
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| The Daily Show with Jon Stewart (1999) | Herself | TV Show |
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