| cast |
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| Series Regulars | |||
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| Bruno Campos | Bruno Campos as Dr. Quentin Costa | Dylan Walsh | Dylan Walsh as Dr. Sean McNamara |
| Jessalyn Gilsig | Jessalyn Gilsig as Gina Russo | Joely Richardson | Joely Richardson as Julia McNamara |
| John Hensley | John Hensley as Matt McNamara | Julian McMahon | Julian McMahon as Dr. Christian Troy |
| Kelly Carlson | Kelly Carlson as Kimber Henry | Kelsey Lynn Batelaan | Kelsey Lynn Batelaan as Annie McNamara |
| Portia de Rossi | Portia de Rossi as Olivia Lord | Roma Maffia | Roma Maffia as Liz Cruz |
| Vanessa Redgrave | Vanessa Redgrave as Dr. Erica Noughton | | |
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| Recurring & Guests | |||
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| Famke Janssen | Famke Janssen as Ava Moore | Oliver Platt | Oliver Platt as Freddy Prune |
| Rose McGowan | Rose McGowan as Dr. Theodora “Teddy” Lowe | Sharon Gless | Sharon Gless as Colleen Rose |