Film & TV List | Role | Media |
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| Grey's Anatomy (2005–2012) | Dr. Derek Shepherd | TV Show |
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| Private Practice (2009–2012) | Dr. Derek Shepherd | TV Show |
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| Transformers: Dark of the Moon (2011) | Dylan | Movie |
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| Flypaper (2011) | Tripp Kennedy | Movie |
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| Valentine's Day (2010) | Dr. Harrison Copeland | Movie |
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| Made of Honor (2008) | Tom | Movie |
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| Enchanted (2007) | Robert Philip | Movie |
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| Freedom Writers (2007) | Scott Casey | Movie |
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| Brother Bear 2 (2006) | Kenai (voice) | Direct to Video |
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| The Practice (2004) | Dr. Paul Stewart | TV Show |
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| Iron Jawed Angels (2004) | Ben Weissman | TV Movie |
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| Karen Sisco (2003) | Carl Wilkens | TV Show |
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| Lucky 7 (2003) | Peter Connor | TV Movie |
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| About a Boy (2003) | Will | TV Movie |
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| Sweet Home Alabama (2002) | Andrew Hennings | Movie |
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| The Emperor's Club (2002) | Older Louis Masoudi | Movie |
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| Once and Again (2000–2002) | Aaron Brooks | TV Show |
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| Rebellion (2002) | Tyler Rae | Movie |
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| Corsairs (2002) | n/a | TV Movie |
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| Blonde (2001) | Cass | TV Movie |
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| Will & Grace (2000–2001) | Matthew | TV Show |
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| Chestnut Hill (2001) | Michael Eastman | TV Movie |
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| Scream 3 (2000) | Detective Mark Kincaid | Movie |
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| Me and Will (1999) | Fast Eddie | Movie |
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| Ava's Magical Adventure (1998) | Jeffrey | Movie |
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| Jeremiah (1998) | Jeremiah | TV Movie |
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| Life in the Fast Lane (1998) | The Stranger | Movie |
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| Crime and Punishment (1998) | Rodya Raskolnikov | TV Movie |
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| The Treat (1998) | Mike | Movie |
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| The Escape (1998) | Clayton | TV Movie |
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| Denial (1998) | Sam | Movie |
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| Hugo Pool (1997) | Floyd Gaylen | Movie |
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| 20,000 Leagues Under the Sea (1997) | Pierre Arronax | TV Movie |
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| The Player (1997) | Griffin Mill | TV Movie |
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| Odd Jobs (1997) | n/a | TV Movie |
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| A Season in Purgatory (1996) | Harrison Burns | TV Movie |
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| The Right to Remain Silent (1996) | Tom Harris | TV Movie |
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| Bloodknot (1995) | Tom | TV Movie |
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| Outbreak (1995) | Jimbo Scott | Movie |
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| With Honors (1994) | Everett Calloway | Movie |
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| J.F.K.: Reckless Youth (1993) | John F. Kennedy | TV Movie |
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| Bank Robber (1993) | Billy | Movie |
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| For Better and for Worse (1993) | Robert Faldo | TV Movie |
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| Face the Music (1993) | Charlie Hunter | Movie |
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| Mobsters (1991) | Meyer Lansky | Movie |
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| Run (1991) | Charlie Farrow | Movie |
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| The General Motors Playwrights Theater (1991) | n/a | TV Show |
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| Coupe de Ville (1990) | Robert 'Bobby' Libner | Movie |
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| The Super Mario Bros. Super Show! (1989) | The Plant | TV Show |
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| Happy Together (1989) | Christopher Wooden | Movie |
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| Loverboy (1989) | Randy Bodek | Movie |
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| Some Girls (1988) | Michael | Movie |
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| In a Shallow Grave (1988) | Potter Daventry | Movie |
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| Can't Buy Me Love (1987) | Ronald Miller | Movie |
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| In the Mood (1987) | Ellsworth 'Sonny' Wisecarver | Movie |
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| Meatballs III: Summer Job (1987) | Rudy | Movie |
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| Fast Times (1986) | Mike Damone | TV Show |
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| Walt Disney's Wonderful World of Color (1986) | Kellin Taylor | TV Show |
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| Heaven Help Us (1985) | Corbet | Movie |
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Film & TV List | Role | Media |
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| Lopez Tonight (2011) | Guest | TV Show |
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| Late Show with David Letterman (2006–2011) | Himself
/
Himself - Guest | TV Show |
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| The Tonight Show with Jay Leno (2007–2011) | Himself
/
Himself - At the MTV Movie Awards | TV Show |
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| Entertainment Tonight (2006–2010) | Himself | TV Show |
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| Extreme Makeover: Home Edition (2009) | Himself | TV Show |
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| The View (2009) | Himself | TV Show |
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| The Insider (2007) | Himself | TV Show |
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| The Oprah Winfrey Show (2006) | Himself | TV Show |
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| The Daily Show with Jon Stewart (1997–2002) | Himself | TV Show |
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