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| Tim Russ as Frank Samantha Who? Tim Russ | Kevin Dunn as Howard Samantha Who? Kevin Dunn | Jennifer Esposito Samantha Who? Jennifer Esposito | Christina Applegate Samantha Who? Christina Applegate |
| Jean Smart Samantha Who? Jean Smart | Jennifer Esposito Samantha Who? Jennifer Esposito | Jennifer Esposito Samantha Who? Jennifer Esposito | Melissa McCarthy Samantha Who? Melissa McCarthy |
| Jean Smart Samantha Who? Jean Smart | Barry Watson as Todd Samantha Who? Barry Watson | Melissa McCarthy Samantha Who? Melissa McCarthy | Samantha Who? cast Samantha Who? |
Recurring & Guests