| cast |
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| Series Regulars | |||
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| Dave Franco | Dave Franco as Cole Aaronson | Donald Faison | Donald Faison as Dr. Christopher Turk |
| Eliza Coupe | Eliza Coupe as Denise | John C. McGinley | John C. McGinley as Dr. Perry Cox |
| Judy Reyes | Judy Reyes as Carla Espinosa | Ken Jenkins | Ken Jenkins as Dr. Bob Kelso |
| Kerry Bishé | Kerry Bishé as Lucy | Michael Mosley | Michael Mosley as Drew |
| Neil Flynn | Neil Flynn as The Janitor | Sarah Chalke | Sarah Chalke as Dr. Elliot Reid |
| Zach Braff | Zach Braff as Dr. John "J.D." Dorian | | |
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| Recurring & Guests | |||
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| Christa Miller | Christa Miller as Jordan Sullivan | Elizabeth Banks | Elizabeth Banks as Dr. Kim Briggs |