| cast |
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| Series Regulars | |||
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| Kaley Cuoco | Kaley Cuoco as Penny | Johnny Galecki | Johnny Galecki as Leonard Hofstadter |
| Simon Helberg | Simon Helberg as Howard Wolowitz | Jim Parsons | Jim Parsons as Sheldon Cooper |
| Kunal Nayyar | Kunal Nayyar as Raj Koothrappali | | |
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| Recurring & Guests | |||
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| Mayim Bialik | Mayim Bialik as Amy Farrah Fowler | Melissa Rauch | Melissa Rauch as Bernadette Rostenkowski |
| Aarti Mann | Aarti Mann as Priya Koothrappali | Kevin Sussman | Kevin Sussman as Stuart |
| Sara Gilbert | Sara Gilbert as Leslie Winkle | Alice Amter | Alice Amter as Mrs. Koothrappali |
| Brian George | Brian George as Dr. Koothrappali | Sara Rue | Sara Rue as Stephanie Barnett |
| Laurie Metcalf | Laurie Metcalf as Mary Cooper | Wil Wheaton | Wil Wheaton as Self |
| Christine Baranski | Christine Baranski as Beverly Hofstadter | | |