| cast |
| Jack Black | Jack Black as Brad Harris | Owen Wilson | Owen Wilson as Kenny Bostick |
| Rosamund Pike | Rosamund Pike as Jessica | Kevin Pollak | Kevin Pollak as Jim Gittelson |
| Joel McHale | Joel McHale as Barry Loomis | Dianne Wiest | Dianne Wiest as Brenda |
| Brian Dennehy | Brian Dennehy as Raymond | Anthony Anderson | Anthony Anderson as Bill Clemont |
| Jim Parsons | Jim Parsons as Crane | Anjelica Huston | Anjelica Huston as Annie Auklet |
| Rashida Jones | Rashida Jones as Ellie | Tim Blake Nelson | Tim Blake Nelson as Fuchs |
| Al Roker | Al Roker as New York Weatherman | Steven Weber | Steven Weber as Rick McIntire |
| Calum Worthy | Calum Worthy as Colin Debs | Corbin Bernsen | Corbin Bernsen as Gil Gordon |
| Nate Torrence | Nate Torrence as Ted Simkin | Cindy Busby | Cindy Busby as Susie |
| JoBeth Williams | JoBeth Williams as Edith | John Cleese | John Cleese as Historical Montage Narrator |
| Paul Campbell | Paul Campbell as Tony | Steve Martin | Steve Martin as Stu Preissler |
| Veena Sood | Veena Sood as Nurse Katie | Zahf Paroo | Zahf Paroo as Prasad |